White box inside a complicated web of cytokine signaling with text that reads Click to explore the complexities

Learn about the role of phosphodiesterase-4 (PDE4) in psoriatic disease. Psoriatic inflammation is caused by a complicated web of cytokine signaling and is not fully understood. Explore the etiology of psoriasis and the relationship with pro and anti-inflammatory cytokines.

PSORIATIC DISEASE IS COMPLICATED1

The etiology of psoriasis is complex and is based on an intricate relationship between environmental and genetic influences that paves the way for disease-initiating events1-3
Inflammation is caused by a complicated interplay of cytokine signaling11
ROLE OF PDEs
cAMP is a key secondary messenger for a variety of inflammatory mediators, and PDEs regulate their intensity, duration, and signaling pathways within immune cells14-16
PDE4 and Immune Cells
PDE4 is present in both circulating and activated pro-inflammatory cells of the immune system16,20
ROLE OF PDE4 IN PRO-INFLAMMATORY CELLS
PSORIATIC DISEASE IS COMPLICATED
LEARN MORE ABOUT PDE4 AND ITS ROLE IN PSORIATIC INFLAMMATION
Explore the resource headquarters
SIGN UP TO RECEIVE UPDATES
Fill in your information below to receive up-to-date information
THANK YOU FOR REGISTERING
You are now registered to receive information and updates. Thank you for your interest in learning more about PDE4 and its role in psoriatic disease.

1.7229018211365